Rehabilitation Program after Cell Therapy for Treatment of Femoral Head Osteonecrosis: A Narrative Review of Literature
نویسنده
چکیده
Recent development in the clinical application of cell therapy is potentially useful for treatment of osteonecrosis of the femoral head (ONFH). Rehabilitation is essential to improve the hip joint function and activity of patients. Rehabilitation program after cell therapy for ONFH treatment and other regenerative medicine fields is known. This narrative review aimed to assess the actual state of the rehabilitation program after cell therapy for ONFH. Seventeen publications met the inclusion criteria and were included in the review. This review focused on weight bearing, muscle strength exercise, range of motion exercise, and physical activity. Considerable information is available on weight bearing, but data on muscle strength exercise, range of motion exercise, and physical activity are insufficient. The initial timing of weight bearing may influence the result. Biomechanical, biophysical, physiological, and radiological knowledge are essential in designing the protocol. Moreover, knowledge on cell biology is required to promote the effect of cell therapy.
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Available Findings Fail to Provide Strong Evidence of the Role of Bone Morphogenic Protein-2 in Femoral Head Osteonecrosis
Despite widespread research on non-traumatic femoral head osteonecrosis (FHON), there is no consensus about preventative treatment options. Insufficient blood supply and increased intra-osseous pressure are the initiating events in the majority of cases. BMPs are growth factors that belong to the transforming growth factor β (TGFβ) superfamily. Two specific formulations of BMPs have already bee...
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